Lindsey seeks to understand how cellular stress pathways are deregulated in pancreatic cancer, with the ultimate aim of identifying new potential therapeutic targets to treat this devastating malignancy. As a graduate student in Dr. David Allis’s laboratory at The Rockefeller University, she used both ChIP- and RNA-sequencing approaches to study a chromatin complex involved in the regulation of the oxidative and nutrient stress pathways. Through her graduate studies, she became interested in how altered regulation of cellular stress pathways contributes to human cancer development. Since joining the Tuveson Laboratory, she has been helping to develop a novel ex-vivo organoid three-dimensional culture system, which allows for rapid grow and manipulation of mouse or human normal, premalignant, or malignant pancreatic ductal cells. She is now using organoid and mouse models to determine how proteotoxic stress contributes to pancreatic cancer development and identifying vulnerabilities in proteotoxic stress pathways which could be targeted to develop novel treatments for pancreatic cancer.