After completing internal medicine training, Sandeep joined the laboratory of Dr. Jill Smith at Georgetown University as a postdoctoral fellow through the TL1-Scholars program. His research focused on the mechanisms of dietary-fat-induced pancreas cancer growth, the role of gastrin in pancreatic carcinogenesis, and the use of a cholecystokinin antagonist in treating chronic pancreatitis. Sandeep then completed his clinical fellowship in gastroenterology at Georgetown. After completing his clinical fellowship, Sandeep joined the Tuveson laboratory to study fibroblasts in the pancreas and their role in chronic inflammation and neoplasia.